The 10 most alternative cities in South America
Discover South America's top 10 alternative cities! From Valparaíso's vibrant streets to La Paz's high-altitude charm and Medellín's innovative spirit.
May in La Serena brings pleasant temperatures, with highs of 19°C (66°F) and nights dropping to 12°C (54°F). With excellent weather conditions overall, it's a good time to visit.
Our weather planner can help you find worldwide destinations with pleasant weather during this period. January, February, March, April, May, August, September, October, November and December typically offer the best weather for La Serena.
Pick a month to see the average temperature, rainfall and sunshine in La Serena - and find the best time to visit.
50-year average (1976-2025)
Based on our historical records, temperatures in La Serena typically stay consistent throughout May, with daily highs averaging around 19°C (66°F). Nights are cool, with lows typically ranging from 9°C (48°F) to 11°C (52°F).
Browse day-by-day weather records for La Serena spanning 51 years. Select any month and year to see actual temperatures, rainfall, and conditions recorded on each day.
Based on 50 years of weather observations (1976-2026), these are the most extreme conditions recorded in La Serena.
Find out more about the weather in Chile and which places have the best travel conditions in this month. See all of Chile in May →
Perfect weather is subjective. On this map perfect weather has been defined with temperatures between 20°C (68°F) and 29°C (84°F) and not too much precipitation (less than 90 mm (3.5 in) a month).
Comfortable temperatures call for an easy wardrobe in May. Pack summer basics like t-shirts and shorts, but include a light jacket for cooler moments. A pair of comfortable walking shoes is essential. Light rain is possible, so consider bringing a small umbrella or rain jacket. Sunglasses could come in handy during the sunnier parts of your trip.
We rated the following activities from 1 (least suitable) to 10 (best) to do.
Temperature Rainfall Sunshine Humidity
See the full La Serena climate overview or explore weather in Chile.
Where to go in May - average daytime high across popular destinations.
Need travel inspiration? Check out our bucket list articles and be inspired.
The 10 most alternative cities in South America
Discover South America's top 10 alternative cities! From Valparaíso's vibrant streets to La Paz's high-altitude charm and Medellín's innovative spirit.
Torres del Paine
Torres del Paine is an huge national park on the border with Argentina. It is possible to walk here along craters, high-rising mountain ridges, over glaciers and through vast majestic tundra.
Explore Patagonia
A tour through Patagonia brings you to the end of the world. That’s why Patagonia is a bucket list destination for many. We recommend to visit Patagonia from November to early March.
Enjoy the silence and peace in a spectacular landscape
This lodge guarantees privacy and exclusivity for those seeking to get away from mass tourism and enjoy the silence and peace in a spectacular landscape.